Inosine Monophosphate Dehydrogenase as a Probe in Antiviral Drug Discovery
نویسندگان
چکیده
منابع مشابه
Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.
Inosine monophosphate (IMP) dehydrogenase (IMPDH) is a significant enzyme in the purine nucleotide biosynthetic pathway. IMPDH is viewed as an important biological target in the quest for drugs in the antiviral therapeutic area. This review article is focused on the chemistry and biology of IMPDH inhibitors and the use of IMPDH inhibition data as a probe in antiviral drug discovery. Examples of...
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In previous studies of purine ribonucleotide metabolism in the human myeloid leukemia cell line HL-60, we observed that there is a down-regulation of guanine ribonucleotide biosynthesis from the central intermediate, inosine monophosphate (IMP) and a depletion of intracellular guanosine triphosphate (GTP) and guanosine diphosphate (GDP) pools that occur during the induced maturation of these ce...
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ژورنال
عنوان ژورنال: Antiviral Chemistry and Chemotherapy
سال: 2007
ISSN: 2040-2066,2040-2066
DOI: 10.1177/095632020701800501